I'm running W11 IoT LTSC on my Z390/I9-9900KF/64GB DDR4 system and it seems OK. I've disabled Defender from completely running and it feels snappier. Also I've removed Copilot and the AI cr@p, disabled most of the background apps that runs at startup. ExplorerPatcher is also useful as it gives me the smaller W10 taskbar back.
Overall it seems stable enough.
Steve